Transportation:

Return transportation from and to the RAI will be provided for all delegates registered for the workshop

Course 1

12:30 RAI - VU Medisch Centrum
15:00 VU Medisch Centrum - RAI

Course Description:

After attending this course, attendees should be able to:

• Describe indications for SABR in a Stage I NSCLC and oligometastases, and the use of 'risk adapted' fractionation schemes
• Understand use of 4-D imaging, cone-beam CT scans and volumetric modulated arc in delivery of SABR
• Appreciate the steps in treatment planning and verification during concurrent chemoradiotherapy in Stage III NSCLC

Preliminary Agenda:

Chair: Suresh Senan, Netherlands

Presentations

• SABR for Stage I NSCLC - Patient Selection, Fractionation Schemes - Cornelius Haasbeek, Netherlands
• Oligometastases: Indications and Dose Fractionation Schemes - Max Dahele, Netherlands
• SABR for Lung Malignancies - Imaging & Physics Considerations - Wilko Verbakel, Netherlands
• IGRT Protocol for a Stage III Lung Cancer - Suresh Senan, Netherlands

Demonstrations

• Motion Phantom and 4D Workstation - Johan van Sornsen de Koste, Netherlands
• Demonstration of on-line imaging on a linear accelerator: Cone-beam CT, Gated Kilo-Voltage Images, Megavolage Cine Movies, Intra-Fraction Motion Review Software - Johan Cuijpers, Netherlands

Time:

13:00 - 14:30

Transportation:

Return transportation from and to the RAI will be provided for all delegates registered for the workshop

12:30 RAI - Academic Medical Center
14:30 Academic Medical Center - RAI

Course Description:

The aim of this course is that

• Attendees learn the value of interdisciplinary discussion about treatment choices and
• Attendees have tools for organizing comparable meetings at home

All members of the multidisciplinary treatment and consultant team (lung physician, pathologist, radiologist, nuclear medicine physician, radiation oncologist, medical oncologist, thoracic surgeon) will together demonstrate and discuss several cases. As in our daily practice another hospital will participate by a videoconferencing system. The main purpose is to show how diagnostic and treatment dilemmas will be approached and which decisions will be made. In some cases follow-up data will be present to assess the effects on the outcome of the treatment as applied. The discussion will especially focus on patients with stage III NSCLC with the questions: is concurrent radiochemotherapy an option, which patients are candidates for surgery after radiochemotherapy? Also patients with mediastinal tumors will be discussed.

After e.g. two cases the audience will be invited to participate in cases that will be discussed next.

Preliminary Agenda:

6 cases will be interactively discussed with the audience

The main focus will be on patients with Stage IIIA en Stage IIIB NSCLC, to discuss for each individual case that will be presented after the diagnostic period the (im)possibilities of concurrent radiochemotherapy, the surgical option in some selected patients, tumors located in the mediastinum. Sometimes more diagnostic procedures are mandatory to make an optimal decision. The meeting deals with the taylor-made approach and according to the national guidelines, if applicable.

Transportation:

Return transportation from and to the RAI will be provided for all delegates registered for the workshop

12:30 RAI - NCI
17:00 NCI - RAI

Course Description:

After attending this course, attendees should be able to

• Understand the relevance of imaged guided radiotherapy for lung cancer patients
• Describe indications for SBRT and high dose RT

Group A:   
Lectures
Demonstrations in the Department of Radiation Oncology

Group B:   
Demonstrations in the Department of Radiation Oncology
Lectures

Lectures (Group A: 13:25 - 14:40 / Group B: 15:10 - 16:25)

• Functional Imaging in Lung Cancer – Wouter Vogel, Netherlands
• SBRT Treatment Planning – Andrea Holt, Netherlands
• 4D Cone Beam CT Guidance and Adaptive RT for Lung – Jan-Jabob Sonke, Netherlands
• SBRT and IMRT at the Clinical Resuts – Jose Belderbos, Netherlands
• Normal Tissue Complication Probability Models and their Applications – Andrew Hope, Canada

Break: 14:40 - 15:10

Demonstrations (Group A: 15:10 - 16:25 / Group B: 13:25 - 14:40)

• Tour through the department – Rick Haas, Netherlands
• How to implement a 4D CT Scan for Treatment Planning? – Jasper Nijkamp, Netherlands
• Target Volume Definition and Delineation Using Multi-Modality Imaging – Joost Knegjens, Netherlands & Heike Peulen, Netherlands
• Treatment Planning for IMRT – Annemarie Lakeman, Netherlands & Emmy Lamers, Netherlands
• SBRT using 4D CBCT Image Guidance – Maddalena Rossi, Netherlands

Drinks: 16:25 - 17:00

During the demonstrations you will have hands-on (max. 12 persons per group) in different parts of the department.

Transportation:

Return transportation from and to the RAI will be provided for all delegates registered for the workshop

Course 1

12:30 RAI - VU Medical Center
15:00 VU Medical Center - RAI

Course 2

15:30 RAI - VVU Medical Center
18:00 VVU Medical Center - RAI

Course Description:

The aim of the workshop is to give the participants an idea of how eLearning can play a role with respect to quality improvement of the use of PET-CT in NSCLC patients (communication between the different disciplines and quality of reporting PET-CT studies).

Preliminary Agenda:

13:00 - 13:10 Need for Improvement of the Quality of the PET-CT report in NSCLC from a Clinical Perspective - Idris Bahce, Netherlands

13:10 - 13:20 Standardization of Patient Preparation and Image Acquisition/Reconstruction in PET-CT - Ronald Boellaard, Netherlands

13:20 - 13:30 Standardization of the PET-CT Report - Emile Comans, Netherlands

2 clinical cases from the VUMC eLearning environment (remote desktop connection for advanced viewing of images)

Attendees are requested to bring their own laptop to log in to the VUMC eLearning environment.

Course Description:

Fundamental concepts of statistics for the clinical investigator will be presented in this course, including p-values, significance, power, sample size estimation, endpoints in survival analysis, Kaplan Meier curves, HR, Cox regression analysis, interaction and subgroup analysis.

The course will be interactive and participants will be encouraged to answer questions and contribute to the discussion of examples. The accent will be on the practical and intuitive understanding of the concepts rather than on the mathematics. The objective is to allow clinical researchers to successfully interpret scientific publications.

Course material will include copy of the slides and a list of useful references for further reading.

Preliminary Agenda:

13:00 - 13:45 Lecture 1: Covering p-Values, Significance, Power, Sample Size Estimation, Kaplan-Meier, Logrank - Mary Redman, USA

13:45 - 14:30 Lecture 2: Covering endpoints in Survival Analysis, Multivariate Cox Regression, Subgroups and False Positives, Interaction - Stefan Michiels, Belgium

14:30 - 15:00 Interactive Discussion of a recent medical paper - Mary Redman, USA & Stefan Michiels, Belgium

Transportation:

Return transportation from and to the RAI will be provided for all delegates registered for the workshop

Course 1

12:00 RAI - VU Medical Center
15:30 VU Medical Center - RAI

Course Description:

EGFR mutation and ALK analysis are crucial biomarkers for individualized treatment of patients with lung cancer. Short lectures will be provided on HOW to test: e.g. specific techniques for EGFR mutation analysis used in different countries around the world (PCR-sequencing, Mass spec, Cycleave, PCR- Invader, PCR clamping, DXS kit, high resolution melting) and ALK analysis (immunohistochemistry and in-situ hybridization) and pathology reporting.

Preliminary Agenda:

Chair: Erik Thunnissen, Netherlands

• Presentation: Histology / Cytology input for DNA Analysis - Erik Thunnissen, Netherlands
• Presentation: PCR Sequencing, Mass Spec - Maria Arcila, USA
• Presentation: Cycleave, PCR-Invader, PCR Clamping - Yasushi Yatabe, Japan
• Presentation: High Resolution Melting - Danielle Heideman, Netherlands
• Break
• Presentation: Pyrosequencing / Cold PCR - Michelle Wood, UK
• Presentation: (Quantitative) Immunohistochemistry limitations - Erik Thunnissen, Netherlands
• Presentation: ALK Immunohistochemistry - Jin-Haeng Chung, Korea
• Presentation: ALK Fluorescent In-Situ Hybridisation - Marileila Garcia, USA
• Presentation: EQA/Pathology Reporting - Erik Thunnissen, Netherlands

CANCELLED

Course Description:

After a theoretical introduction in CRM a role-playing team shows 2 different clinical scenarios to demonstrate various manners of team-interaction, illustrating the impact of CRM for patient safety. The clinical scenario will be presented in a stepwise manner to the participants in the audience. Each participant will be given a voting pad and follow the clinical scenario live and by video-stream.

Every step will be discussed in a proactive manner, moderated by experts and the team will execute the chosen decision by the audience. The consequence of handling as requested by the audience will have impact on the following steps. Changes in vital parameters and clinical situation will subsequently become apparent, which urges the team to execute the next step after consultation with the audience.

Preliminary Agenda:

• Presentation: ‘Crew Resource Management and Patient Safety’
• ‘Stop and Go’ Scenario 1: Interactive simulation with ‘full scale patient simulator’, live-bronchoscopy of the manikin and team-(inter)action via live stream, audience participation via voting pads
• ‘Stop and Go’ Scenario 2
• Discussion

Course Description:

The aim of this course is to

• review indications and limitations of EBUS and EUS for lung cancer staging
• understand the complimentary role in mediastinal staging in collaboration with the surgical oncologists
• practice with various EBUS and EBUS scopes and different types of needles on dummies and a simulator
• learn how to translate ultrasound images to the new TNM classification
• discuss value of endosonography in relation to surgical staging techniques
• discuss the place of endosonography in lung cancer staging algorithms
• learn how to set up an EUS/EBUS service

Preliminary Agenda:

Chair: Jouke Annema, Netherlands & Felix Herth, Germany

• Presentation: Mediastinal Anatomy and TBNA - Ko-Pen Wang, USA
• Presentation: EBUS Technique, Nodal Anatomy, How to do it - Felix Herth, Germany
• Presentation: EUS Technique, Nodal Anatomy, How to do it - Jouke Annema, Netherlands
• Hands On Part 1 (Rotating)
  • EBUS Linear - Jouke Annema, Netherlands & Felix Herth, Germany
  • EUS Linear - Arthur Szlubowski, Poland & Kurt Tournoy, Belgium
  • Endosonography - Ko-Pen Wang, USA
• Break
• Hands On Part 2
  • EBUS Linear - Jouke Annema, Netherlands & Felix Herth, Germany
  • EUS Linear - Arthur Szlubowski, Poland & Kurt Tournoy, Belgium
  • Endosonography - Ko-Pen Wang, USA
• Interactive Cases Discussion - Arthur Szlubowski, Poland
• How to Set Up an Endosonography Service - Kurt Tournoy, Belgium
• Post Course Assessment

Course Description:

The aim of this course is to improve the selection, planning and performance of pleural procedure for the diagnosis, active treatment and palliation of thoracic malignancy.

After this course, attendees should

• understand the principles and application of pleural ultrasound to identify critical normal structures and thus avoid procedural complications
• be able to use ultrasound to guide pleural fluid sampling and biopsy
• be able to more safely insert intercostal catheters and tunneled pleural fluid drainage systems
• be able to place pleural catheters to aid the management of pain in suitable patients with mesothelioma

Suggestions for pre-reading material will be supplied in advance of the WCLC.

Preliminary Agenda:

Chairs: Michel van den Heuvel, Netherlands, Matthew Peters, Australia & Paul Baas, Netherlands

• Introduction - Michel van den Heuvel, Netherlands, Matthew Peters, Australia
• Hands-On Part 1
  • Thoracic Ultrasound - Fergus Gleeson, UK
  • Alternative Palliative Procedures for Pleural Disease - Matthew Peters, Australia
  • Ultrasound Guided Needle Biopsies - Warner Prevoo, Netherlands
  • Pleurel and Tunneled Indwelling Catheter and Drainage Systems - Michel van den Heuvel, Netherlands
• Break
• Hands-On Part 2
  • Thoracic Ultrasound - Fergus Gleeson, UK
  • Alternative Palliative Procedures for Pleural Disease - Matthew Peters, Australia
  • Ultrasound Guided Needle Biopsies - Warner Prevoo, Netherlands
  • Pleurel and Tunneled Indwelling Catheter and Drainage Systems - Michel van den Heuvel, Netherlands
• Complementary Lecture on Palliative Care and Pain Management
• Group Discussion

Course Description:

The aim of this course is to optimize diagnosis and treatment of early lung cancer in the central airways and diagnosis of small peripheral lung lesions and to discuss the role of the endoscopist as part of a multi-disciplinary team in the management of early lung cancer.

Following short lectures, the twenty participants will rotate through different stations to test their bronchoscopy skills. Self-exercise by participants using different autofluorescence and narrow band imaging systems, different types of videobronchoscopes, radial ultrasound probes and virtual bronchoscopic navigation. Learn the tissue effects of applying electrocautery, argon plasma coagulation and cryotherapy.

Literature list will be provided in due course.

Preliminary Agenda:

Chairs: Joachim Aerts, Netherlands & Stephen Lam, Canada

• Welcome & Lunch
• Concepts of Early Intervention and Spectral Imaging - Joachim Aerts, Netherlands
• Procurement, Processing and Interpretation of Small of Bronchoscopic Biopsy Specimens - Katrien Grunberg, Netherlands
• Tissue Effects of Electrocautery, Plasma Argon Coagulation and Cryotherapy -Bill Krimsky, UK
• Construction of Virtual Bronchoscopy Map - Fumihiro Asano, Japan
• Break
• Hands-On Session
• AF bronchosocpy. Electrocautery, Argon Plasma Coagulation and Cryotherapy - Joachim Aerts, Netherlands & Bill Krimsky, UK
• Virtual Bronchoscopy - Stephen Lam, Canada
• Bronchoscopy Simulator - Thomas Sutedja, The Netherlands
• Localization of Peripheral Lung Lesions using Ultrathin Brochoscope, Radial Ultrasound - Fumihiro Asano, Japan & Colleagues
• Pathology and Cytology Processingr - Katrien Grunberg, The Netherlands
• Evaluation and Feedback

Course Description:

The aim of this course is to provide participants with knowledge and skills to work with rigid bronchoscopy and its applications, with special focus on malignant disease (debulking and stenting) and to inform the audience with current development in tracheal bio-engineering.

Through the use of models and several rigid bronchoscopy systems, the principles or rigid bronchoscopy are demonstrated. With additional models the participants can acquire skills on relevant techniques for treating malignant airway disease. The participants can practice debulking of central lung tumors and the positioning of several types of stents (silicone and expandable) in the airways.

Preliminary Agenda:

Chairs: Hans Daniels, Netherlands & Herve Dutau, France

• Lunch and Welcome
• Setup & Handling of the rigid bronchoscopy - Christophe Dooms, Belgium
• Hands-On Session 1: Introduction & Handling
• Debulking of Central Airway Lesions - Herve Dutau, France
• Hands-On Session 2: Debulking of Central Airway Lesions
• State-of-the-art Lecture: Allotransplantation, bio-engineering and Other Techniques for Reconstruction of Tracheal Defects - Emmanuel Martinod, France
• Airway Stenting - Lutz Freitag, Germany
• Hands-On Session 3: Stenting a Central Airway Tumor

Course Description:

The aim of the course is to discuss how to optimize management  of the airway in interventional bronchoscopy and how to cope with massive haemoptysis or endobronchial bleeding with both rigid and flexible bronchoscopy.

The primary importance of securing airway passage with anticipation of difficult airway management for optimal ventilation are key elements before acquiring the different competency skills in pulmonary endoscopic procedures. For difficult major airways manoeuvring, the importance in training for rigid bronchoscopy competence will also be dealt with. Strategies during flexible bronchoscopy and use of balloon blockers will also taught.

Role playing team to mimic airway haemorrhage and practice the airway bleeding management drill will be executed by attendants under guidance of tutors as well as introductory skills in performing rigid bronchoscopy and use of balloon blockers with flexible bronchoscopy.

Preliminary Agenda:

Chairs: Pallav Shah, Uk, Suveer Singh, UK & Dirk-Jan Slebos, Netherlands

• Radiological Interventions for Massive Haemoptysis - Timothy Overtoom, Netherlands
• Aetiology of Massive Haemoptysis - Suveer Singh, UK
• Stop & Go Scenario for Massive Haemoptysis - Pallav Shah, UK & Suveer Singh, UK
• Baloon Blockers - Pallav Shah, UK
• 15:00 – 17:00 Hands-On Workshops (rotation)
  • Management of Upper Airway & Intubation Skills - Pallav Shah, UK
  • Rigid Bronchoscopy - Simon Jordan, UK & Nico van Walree, Netherlands
  • Use of Arndt Blocking Balloons - Dirk-Jan Slebos, Netherlands
  • Use of Cohen Blocking Baloons - Pallav Shah, UK